Sleep disturbance: Complementary therapies


One RCT (with an unknown risk of bias) identified in a Systematic Review (with a moderate risk of bias) in peri- and early postmenopausal women (with hot flushes and at least one co-occurring symptom) found that an isoflavone combination significantly reduced insomnia at 12 weeks; other trials found that soy and other isoflavones did not significantly improve sleep symptoms.75 [ES55]

Omega-3 fatty acids

One RCT (with a low risk of bias) in peri- and postmenopausal women reported no significant effect on sleep quality and insomnia with omega-3 fatty acid supplementation compared to placebo.76 [ES56]

Vitamin E

One RCT (with a moderate risk of bias) in women after breast cancer found that Vitamin E (800 IU/d for 12 weeks) was inferior to gabapentin (900mg/d for 12 weeks) at reducing sleep disturbance.33 [ES24]