Summary of Evidence - Sleep disturbance

Sleep disturbance is a common menopausal symptom in women after breast cancer and includes poor quality of sleep, restless sleep, sleepiness, trouble sleeping, difficulty sleeping, interrupted sleep, unrefreshing sleep and insomnia.

Nineteen RCTs out of the 45 studies included in the primary systematic review reported sleep disturbance outcomes during treatment for menopausal symptoms in women after breast cancer. Only two studies had sleep disturbance as a primary outcome measure; all other studies reported sleep disturbance symptoms as a secondary outcome, or as an adverse event.

Five systematic reviews and three RCTs identified in the supplementary evidence review reported the effect of one or more interventions on sleep disturbance.