Mood and emotional wellbeing: Hormonal interventions

Menopause hormone therapy

One RCT (with a low risk of bias) in women after breast cancer found a statistically significant improvement in depressed mood for tibolone (2.5mg/d for a mean of 2.5 years) compared with placebo.35

Other hormone therapies

In a population of peri- and postmenopausal women, two RCTs in a systematic review found that the addition of testosterone to menopause hormone therapy had no effect on overall wellbeing.44 In a population of postmenopausal women, nine RCTs found that testosterone reduced personal distress, but other RCTs in the systematic review found that testosterone had no effect on anxiety (four RCTs) or depressed mood (five RCTs).87