Book traversal links for Unanswered questions
Important unanswered questions about the management of CNS metastases in women with metastatic breast cancer are outlined below. Some of these questions may be addressed in ongoing trials.
- The optimal timing of whole brain radiotherapy (WBRT) and local therapies, with outcomes relating to quality of life and overall survival.
- The efficacy of surgery alone compared to radiosurgery alone.
- The safety and effectiveness of hippocampal sparing techniques.
- The role of systemic therapies after radiotherapy in patients with triple negative breast cancer.
- Differences between isolated CNS metastases and wider/systemic metastases.
- The impact of brain metastases on quality of life, including changes in appearance, and the impact on carers.
- The efficacy of ‘active’ treatments compared to supportive and/or palliative care alone.
- Supportive care, including rehabilitation requirements, and palliative care needs for women with CNS metastases from breast cancer.
- Differences in approach to treatment based on subtype of breast cancer.