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Cancer of unknown primary

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  2. Treatment
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Treatment options

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Treatment and care of people with cancer is usually provided by a team of health professionals, both medical and allied health, called a multidisciplinary team.

Because the primary cancer is unknown, treatments may differ from person to person. Treatment for cancer of unknown primary depends on:

  • the type of cell that the cancer started from
  • where it has spread to in the body
  • the number of organs that the cancer has spread to
  • your signs and symptoms of cancer
  • the results of your tests and scans
  • your general health
  • your personal preferences.

Treatment options may include surgery, chemotherapy, radiation therapy, hormone therapy and targeted therapy.

Surgery

If the cancer of unknown primary is a solid tumour, your doctor may try to remove it with surgery. Your doctor may also remove lymph nodes. Because the tumour is of unknown primary, you will likely need other treatments other than just surgery, to try to destroy any remaining cancer cells in the body.

Chemotherapy

Most cancers of unknown primary will be treated with chemotherapy. This is because chemotherapy is often used for cancers that have metastasised (spread), because chemotherapy can treat many different types of cells and organs at once.

Chemotherapy may be used to make the tumour smaller before surgery or remove any remaining cancer cells after surgery.

Radiation therapy

You may receive radiation therapy for cancer of unknown primary.

Radiation therapy may also be used to make the tumour smaller before surgery or to remove any remaining cancer cells after surgery.

Radiation therapy may also be used to relieve symptoms of the cancer, such as pain.

Hormone therapy

Hormone therapy may be useful if there is an indication that the primary cancer is breast or prostate cancer. These are cancers that respond to estrogen (such as some breast cancers) or androgens (such as many prostate cancers). Hormone therapy either blocks estrogen or androgen receptors on the cancer cells, or lowers the levels of hormones in your body as a way to slow cancer growth.

Targeted therapy

Targeted therapy may be used if your cancer cells have a certain characteristic for the therapy to target. Laboratory testing is done to check if there are any targeted therapies that may benefit you.

  • Last Updated
  • References
  • Relevant Links
updated: 3 January 2023 - 11:12am

National Cancer Institute. Carcinoma of unknown primary treatment (PDQ): patient version.

American Cancer Society, Cancer of unknown primary
National Cancer Institute (US), Carcinoma of unknown primary treatment (PDQ®), patient version
Australian Cancer Trials

Related information

What is cancer?
What is cancer?

Cancer is a disease of the cells, which are the body’s basic building blocks.

Treatment and side effects
Treatment and side effects

The treatment that your doctors recommend will depend on the type of cancer you have, how advanced it is, and other personal factors.

Living with cancer
Living with cancer

A diagnosis of cancer marks the beginning of a journey full of emotional, psychological, physical and practical challenges.

Life after cancer
Life after cancer

While looking forward to finishing their cancer treatment and getting on with life, for some people, the end of treatment can also be a confusing or worrying time.

A-Z List of Cancer Types

Information on more than 70 types of cancer

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About Cancer Australia

Cancer Australia was established by the Australian Government in 2006 to benefit all Australians affected by cancer, and their families and carers. Cancer Australia aims to reduce the impact of cancer, address disparities and improve outcomes for people affected by cancer by leading and coordinating national, evidence-based interventions across the continuum of care.

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